Publications

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  • Lee, M.H., Mabb, A., Gill, G., Yeh, E.H. & Miyamoto, S. (2011) NF-kB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Molecular Cell. 43, 180–191
  • Yang, Y., Hermance, N., Mabb, A., Simonson, S., Morrissey, S., Gandhi, P., Munson, M., Miyamoto, S. & Kelliher, M.A. (2010) A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kB and p38 MAPK/MAPKAP2 responses to DNA damage. Mol. Cell. Biol. (in press).
  • Wu, L., Shao, L., An, N., Wang, J., Pazhanisamy, S., Feng, W., Hauser-Jensen, M., Miyamoto, S., & Zhou, D. (2011) IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells. PloS One 6:e18447.
  • Wuerzberger-Davis, S.M., Chen, Y., Yang, D.T., Kearns, J.D., Bates, P.W., Lynch, C., Ladell, N.C., Yu, M., Podd, A., Zeng, H., Huang, T.T., Wen, R., Hoffmann, A., Wang, D. & Miyamoto, S. (2011) Nuclear export of the NF-kB inhibitor IkBa is required for proper B cell and secondary lymphoid tissue formation. Immunity 34: 188-200.
  • Miyamoto, S. (2011) Nuclear initiated NF-kB signaling: NEMO and ATM take center stage. Cell Res. 21: 116-130.
  • Lee, M.H., Mabb, A., Gill, G., Yeh, E.H. Miyamoto, S. (2011) NF-kB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Molecular Cell (in press).
  • Yang, Y., Hermance, N., Mabb, A., Simonson, S., Morrissey, S., Gandhi, P., Munson, M., Miyamoto, S. & Kelliher, M.A. (2011) A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kB and p38 MAPK/MAPKAP2 responses to DNA damage. Cell. Biol. (in press).
  • Wu, L., Shao, L., An, N., Wang, J., Pazhanisamy, S., Feng, W., Hauser-Jensen, M., Miyamoto, S., & Zhou, D. (2011) IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells. PloS One 6:e18447. PMID: 21490922
  • Wuerzberger-Davis, S.M., Chen, Y., Yang, D.T., Kearns, J.D., Bates, P.W., Lynch, C., Ladell, N.C., Yu, M., Podd, A., Zeng, H., Huang, T.T., Wen, R., Hoffmann, A., Wang, D. & Miyamoto, S. (2011) Nuclear export of the NF-kB inhibitor IkBa is required for proper B cell and secondary lymphoid tissue formation. Immunity 34: 188-200. PMID: 21333553
  • Miyamoto, S. (2011) Nuclear initiated NF-kB signaling: NEMO and ATM take center stage. Cell Res. 21: 116-130. PMID: 21187855
  • Zhao-Hui Wu*, Ee Tsin Wong, Yuling Shi, Jixiao Niu, Zhijian Chen, Shigeki Miyamoto*, Vinay Tergaonkar. (2010). ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. Mol Cell. 2010 40:75-86. PMID: 20932476
  • Markovina S, Callander NS, O’Connor SL, Xu G, Shi Y, Leith CP, Kim K, Trivedi P, Kim J, Hematti P, Miyamoto S. (2010). Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-kappaB activity in myeloma cells. Mol Cancer. 9:176. PMID: 20604947
  • Wuerzberger-Davis SM, Miyamoto S. (2010). TAK-ling IKK activation: “Ub” the judge. Sci Signal.  19;3(105):pe3 PMID 20086238
  • McCool K, Miyamoto S. (2009). A PAR-SUMOnious mechanism of NEMO activation. Mol Cell. 36:349-50. PMID 19917242
  • Markovina S, Callander NS, O’Connor SL, Kim J, Werndli JE, Raschko M, Leith CP, Kahl BS, Kim K, Miyamoto S. (2008). Bortezomib-resistant nuclear factor-kappaB activity in multiple myeloma cells. Mol Cancer Res. 8:1356-64. PMID 18708367
  • Yang DT, Young KH, Kahl BS, Markovina S, Miyamoto S. (2008). Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma. Mol Cancer. 7:40. PMID 18489772.
  • Wuerzberger-Davis SM, Nakamura Y, Seufzer BJ, and Miyamoto S. (2006). NF-kB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage. Oncogene. 26:641-651. PMID 16862178
  • Mabb A, Wuerzberger-Davis SM, and Miyamoto S. (2006). PIASy mediates NEMO sumoylation and NF-kB activation in response to genotoxic stress. Nature Cell Biol. 8:986-993. PMID 16906147
  • Chang PY and Miyamoto S. (2006). NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells. Cancer Res. 66:6008-6013. PMID 16778171
  • Chang PY and Miyamoto S. (2006). Nuclear factor-kappaB dimer exchange promotes a p21(waf1/cip1) superinduction response in human T leukemic cells. Mol Cancer Res. 4:101-112. PMID 16513841
  • Wu Z, Shi Y, Tibbetts RS, and Miyamoto S. (2006). Molecular linkage between the kinase ATM and NF-kB signaling in response to genotoxic stimuli. Science 311:1141-1146. PMID 16497931 (Perspective: Bartek J and Lukas J. The stress of finding NEMO. Science. 311:1110-1111.)
  • Wu Z, Mabb A, and Miyamoto S. (2005). PIDD: a switch hitter. 123:980-982. PMID 16360026
  • Berchtold CM, Chen K-S, Miyamoto S, and Gould MN. (2005). Perillyl alcohol inhibits a calcium-dependent constitutive NF-kB pathway. Cancer Res. 65:8558-8566. PMID 16166337
  • Wuerzberger-Davis SM, Chang P-Y, Berchtold C, and Miyamoto S. (2005). Enhanced G2/M arrest by NF-kB-dependent p21waf1/cip1 induction. Mol Cancer Res. 3:345-353. PMID 15972853
  • O’Connor S and Miyamoto S. (2005). Evidence for a phosphorylation-independent role for Ser 32 and 36 in proteasome inhibitor resistant (PIR) IkBa degradation. Exp Cell Res. 307:15-25. PMID 15922723
  • O’Connor S, Shumway S, and Miyamoto S. (2005). Inhibition of IkBa nuclear export as an approach to abrogate NF-kB dependent cancer cell survival. Mol Cancer Res. 3:42-49. PMID 15671248
  • Miyamoto S. (2004). RelA life and death decisions. Mol Cell. 13:763-764. PMID 15053867
  • Bates P and Miyamoto S. (2004) Expanded nuclear roles for IkB’s. Science STKE. 254:48. PMID 15479861
  • O’Connor S, Shumway SD, and Miyamoto S. (2004). Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkBa degradation in B cells. Mol Cell Biol. 24:4895-4908. PMID 15143182
  • Huang TT, Davis SM, Wu Z, and Miyamoto S. (2003). Sequential modification of NEMO/IKKg by SUMO-1 and ubiquitin mediates NF-kB activation by nuclear DNA damage. Cell. 115:565-576.  PMID: 14651848 (News and Views: Hay RT. (2004). Modifying NEMO. Nature Cell Biol. 6:89-91.